Oncogenic β-tubulin mutations disrupt nucleotide-dependent allostery and free energy landscape of tubulin dimer

Key Points

• Disrupted nucleotide-dependent allostery results in altered free energy landscape of tubulin dimers, affecting cellular functions.
• The study shows that oncogenic mutations in β-tubulin significantly affect its behavior in response to nucleotides, impacting dimer stability.
• Assessment using structural analysis and molecular simulations illustrates how mutations influence binding properties of tubulin.
• These findings may enable targeted therapies for cancers driven by β-tubulin mutations, highlighting a critical area for further research.