Holotomography-Based, Label-Free Quantification of Cellular Dry Mass as a Biophysical Indicator of Microglial Aβ Phagocytosis during Senescence

Key Points

• Cellular dry mass serves as a key biophysical indicator of microglial Aβ phagocytosis during senescence, revealing potential insights into aging biology.
• Findings show that changes in dry mass correspond with phagocytosis levels, indicating the impact of senescence on microglial function.
• Holotomography was utilized to measure cellular dry mass, providing label-free quantification for assessing microglial activity during senescence.
• Implications of this study may lead to better understanding of microglial behavior in aging, shedding light on neurodegenerative processes.