Intranasal unadjuvanted PspA spikes lung-resident memory immunity after parenteral pneumococcal vaccination

Key Points

• Enhanced lung-resident memory immunity occurs following intranasal PspA administration.
• The study indicates a significant increase in immune response after parenteral pneumococcal vaccination.
• This analysis examines the effects of intranasal unadjuvanted PspA on immunity.
• These findings emphasize the need for novel vaccine strategies to boost immunity effectively.