March 3, 2026Open Access

Clonal relatedness and emerging linezolid resistance in Clostridioides difficile ribotypes 001 and 176 in the Czech Republic

Key Points

Emergence of linezolid-resistant strains in Clostridioides difficile RT001 raises alarm,
WGS identified clonal relatedness among strains across nine hospitals in the Czech Republic,
Incorporating antimicrobial resistance genes improves discriminatory power over cgMLST or wgMLST alone,
Highlights the need for improved monitoring of resistant strains to inform public health actions.

Abstract

RT001 and RT176 predominate in the Czech Republic, and WGS confirmed their inter-hospital clonal relatedness. Importantly, the emergence of linezolid-resistant RT001 strains was detected in nine hospitals. The inclusion of AMR genes in genetic relatedness analysis showed higher discriminatory power compared to cgMLST or wgMLST alone.

Bookmark

View Full Paper

Cite This Study

Marie et al. (Tue,) studied this question.

synapsesocial.com/papers/69a76629badf0bb9e87dbf33 https://doi.org/https://doi.org/10.1016/j.ijid.2026.108444

Bookmark

View Full Paper