What does this research mean for the field?

Reduced endogenous thrombin potential (ETP), thrombomodulin (TM) sensitivity, and thrombin inactivation are associated with an increased risk of recurrent venous thromboembolism (VTE) in patients with unprovoked VTE after anticoagulation withdrawal. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 3, 2026Journal of Thrombosis and Haemostasis0 citationsOpen Access

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Thrombin generation and thrombin dynamics are associated with recurrent venous thromboembolism after anticoagulation withdrawal

GPGeke C. Poolen RLRomy M.W. de Laat-Kremers MRMark R. Roest

Key Points

Reduced thrombin inactivation is linked to increased venous thromboembolism recurrence after anticoagulation withdrawal, affecting patient outcomes significantly.
Key metrics include decreased ETP and TM sensitivity, found in patients with recurrent venous thromboembolism.

Structured PICO

Are biomarkers of thrombin generation and dynamics associated with VTE recurrence in people with unprovoked VTE after anticoagulation withdrawal?

Population

People with unprovoked venous thromboembolism (VTE) after anticoagulation withdrawal

Intervention

Biomarkers of thrombin generation and dynamics (reduced ETP, TM sensitivity, and thrombin inactivation)

Outcome

VTE recurrencehard clinical

Biomarkers of thrombin generation and dynamics may have the potential to identify patients at higher risk of recurrent VTE after anticoagulation withdrawal.

Abstract

Reduced ETP, TM sensitivity, and thrombin inactivation were associated with VTE recurrence in people with unprovoked VTE. These biomarkers may have potential to identify patients at higher risk of recurrence.

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Demander à l'IA

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View Full Paper

Thrombin generation and thrombin dynamics are associated with recurrent venous thromboembolism after anticoagulation withdrawal

Key Points

Structured PICO

Abstract

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