Genistein ameliorates lupus nephritis via enhancing ERβ-mediated inhibition of STAT3-driven inflammation

Key Points

• Genistein significantly reduces inflammation associated with lupus nephritis, indicating its therapeutic potential.
• A key finding is the role of ERβ in inhibiting STAT3, which is crucial for inflammatory responses.
• Analysis employed various biochemical assays to measure the effects of genistein on lupus nephritis models.
• The findings suggest genistein may offer a novel approach for managing lupus nephritis, though clinical studies are needed.