Study on liver injury caused by lipid accumulation induced by PM2.5 through IRE1α-XBP1s pathway of endoplasmic reticulum stress in mice

Key Points

• Liver injury occurs due to lipid accumulation driven by PM2.5 exposure, specifically activating the IRE1α-XBP1s pathway.
• The analysis demonstrated significant disruptions in liver function markers when comparing exposed versus control mice.
• This study utilized a mouse model to explore the role of endoplasmic reticulum stress in mediating liver damage.
• Findings highlight the need to further investigate environmental factors impacting liver health and metabolic processes in humans.