Spike 1 trimer subunit vaccines against porcine epidemic diarrhea virus effectively induce protective immunity challenge in piglets

Key Points

• Protective immunity against porcine epidemic diarrhea virus was effectively induced in piglets by the spike 1 trimer subunit vaccines.
• Immunizations resulted in a robust immune response within weeks following administration, showing significant protection during challenges.
• The study employed an experimental challenge model to assess vaccine efficacy, with specific focus on immune response metrics.
• These findings suggest that spike 1 trimer vaccines may provide a viable option for controlling porcine epidemic diarrhea virus in swine populations.