The high-heel sign: revisiting neurological semiology from Charcot’s era to modern patient-reported outcomes in multiple sclerosis

Key Points

• Neurological semiology provides insights into multiple sclerosis outcomes, especially regarding the high-heel sign.
• The high-heel sign notably correlates with patient-reported experiences in multiple sclerosis cases.
• Analysis utilizes historical observations from Charcot's era to inform current clinical practices and outcomes.
• Implications emphasize the need for integrating historic and modern neurological signs in patient evaluations.