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Visceral obesity-induced METTL27 regulation of the FABP5/PPARD/CPT1A axis in promoting colorectal cancer progression | Synapse
March 3, 2026
Visceral obesity-induced METTL27 regulation of the FABP5/PPARD/CPT1A axis in promoting colorectal cancer progression
SG
Shengnan Gao
QF
Qingxiao Fang
Harbin Medical University
ZR
Zixuan Ru
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Key Points
METTL27 regulation significantly affects the FABP5/PPARD/CPT1A axis, influencing colorectal cancer progression.
Increased visceral obesity correlates with elevated levels of METTL27, impacting cancer-related metabolic pathways.
The study uses molecular analysis to explore the interaction between obesity and the FABP5/PPARD/CPT1A axis.
Findings highlight the potential for targeting these metabolic pathways in cancer treatment strategies.
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Gao et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76743badf0bb9e87e030c
https://doi.org/https://doi.org/10.1016/j.ijbiomac.2026.150740