EEG vigilance and response to oral prolonged-release ketamine in treatment-resistant depression - A double-blind randomized validation study

Key Points

• Response to oral prolonged-release ketamine correlates with EEG vigilance levels, indicating potential therapeutic mechanisms.
• Key findings show significant changes in vigilance metrics with ketamine treatment across various assessment points.
• Double-blind randomized controlled trial was employed to ensure evidence quality using objective EEG measurements.
• Further validation is needed in broader populations to establish long-term effects and practical applications.