Severe renal dysfunction or kidney failure at admission increased 1-year risk of heart failure readmission and all-cause death by 53% compared to mild renal dysfunction (adjusted HR 1.529, 95% CI 1.005–2.326) in older adults with acute heart failure.
Cohort (n=710)
Yes
Does admission renal dysfunction severity predict adverse outcomes in older patients with acute heart failure?
Effect estimate: adjusted HR 1.529 for severe RD or kidney failure vs mild RD (95% CI 1.005–2.326)
p-value: p=0.047
Background: Renal dysfunction (RD) is common at admission for acute heart failure (AHF), but there is limited evidence focusing on older adults and considering the influence of physical function. We evaluated the prognostic significance of admission RD severity as a risk factor for adverse outcomes in older patients with AHF, while considering the potential modifying effect of physical function.
Kito et al. (Thu,) conducted a cohort in Older patients (aged ≥65 years) hospitalized for acute heart failure with admission renal dysfunction (eGFR <60 mL/min/1.73 m2) (n=710). Stratification by admission renal dysfunction severity (eGFR categories) vs. Mild renal dysfunction (eGFR 45–59 mL/min/1.73 m2) was evaluated on Composite of heart failure readmission and all-cause death within 1 year post-discharge (adjusted HR 1.529 for severe RD or kidney failure vs mild RD, 95% CI 1.005–2.326, p=0.047). Severe renal dysfunction or kidney failure at admission increased 1-year risk of heart failure readmission and all-cause death by 53% compared to mild renal dysfunction (adjusted HR 1.529, 95% CI 1.005–2.326) in older adults with acute heart failure.