UPLC-Q-TOF-MS/MS guided isolation of phyllanfranchins A–D, two pairs of undescribed cytotoxic dichapetalin hybrid triterpenoid epimers from Phyllanthus franchetianus

Key Points

• Cytotoxic activity of newly isolated phyllanfranchins A–D was confirmed, with promising potential in cancer treatment.
• The study revealed previously undescribed pairs of epimers, enhancing understanding of chemical diversity.
• UPLC-Q-TOF-MS/MS guided the isolation and characterization of these novel triterpenoid compounds.
• The findings suggest further investigation into the therapeutic potential of these compounds in drug development.