Clinical and treatment-related predictors of complete response after total neoadjuvant therapy for rectal cancer in a large multicenter analysis | Synapse
March 3, 2026Open Access
Clinical and treatment-related predictors of complete response after total neoadjuvant therapy for rectal cancer in a large multicenter analysis
Key Points
Complete response rates are higher with more intensive total neoadjuvant therapy protocols, indicating treatment effectiveness.
A key finding shows that smoking cessation may improve treatment outcomes, highlighting a lifestyle factor in patient recovery.
Observational analysis across multiple centers evaluated clinical and treatment-related predictors of complete response in rectal cancer patients.
Increasing smoking cessation efforts may support treatment success; further validation is needed before implementing changes.
Abstract
More intensive TNT protocols were associated with higher CR rates. Smoking cessation may be beneficial but requires external validation.