Collectively, we have developed a unique genetic signature that is based on genes associated with calcium signaling. This signature possesses the capacity to precisely anticipate the survival prognosis and therapeutic response of BLCA patients and might have a crucial role in guiding clinical treatment. Furthermore, ATP2B4 has been identified as a crucial oncogenic gene. The downregulation of ATP2B4 leads to mitochondrial Ca2+ overload, ultimately resulting in apoptosis of BLCA cells.
Zhang et al. (Fri,) studied this question.