March 3, 2026Open Access

Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury

Key Points

Myocardial ischemia-reperfusion injury is significantly attenuated by the natural products, improving mitochondrial function.
Specific activation of the SIRT1/3-PGC-1α-NRF2 pathway indicates a potential therapeutic target for cardiac protection.
Analysis demonstrates modulation of PINK1/Parkin-dependent mitophagy, vital for restoring mitochondrial homeostasis.
Utilizing these natural products presents a novel approach, yet further studies are needed for clinical validation.

Abstract

PRC attenuates MIRI by activating the SIRT1/3-PGC-1α-NRF2 pathway to modulate PINK1/Parkin-dependent mitophagy, thereby restoring mitochondrial homeostasis. Our study elucidates a novel mechanism underlying this natural product combination and highlights the SIRT1/3 axis as a promising therapeutic target for cardioprotection.

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Authors

Ming Yao

Ye Jin

Hongyu Wei

Journals

Frontiers in Pharmacology

SHILAP Revista de lepidopterología

Actions

Institutions

Changchun University of Chinese Medicine

The Affiliated Hospital to Changchun University of Chinese Medicine

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Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury

Key Points

Abstract

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

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Discussion

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