What lies beyond thioredoxin reductase? Cyclometallated gold compounds reveal Sec selectivity in glutathione peroxidases

Key Points

• Sec selectivity is influenced by cyclometallated gold compounds, providing insights into enzyme catalytic activity.
• The study identified specific interactions that enhance the performance of glutathione peroxidases in cellular environments.
• Employing unique metallated compounds allows for deeper understanding of thioredoxin reductase pathways and mechanisms.
• These findings hint at novel strategies for targeting antioxidant defenses in various diseases, though further research is needed.