The paradox of nuclear miRNAs: Mechanisms, therapeutic potential, and future directions

Key Points

• Nuclear micro RNAs (miRNAs) demonstrate complex roles in gene regulation, influencing both cell behavior and therapeutic strategies.
• This work reveals that nuclear miRNAs affect various pathways, possibly impacting outcomes in a range of diseases and treatments.
• Analysis explores the therapeutic potential of nuclear miRNAs as biomarkers for disease intervention and predictive modeling.
• Understanding these mechanisms may enable new treatments but emphasizes the paradoxical roles miRNAs play in health and disease.