Moderate-to-severe coronary calcification was not significantly associated with 1-year MACE after IVUS-guided PCI (9.4% vs. 6.3%; HR 1.54, 95% CI 0.85–2.79; p=0.157) in adults with coronary artery disease.
Observational (n=914)
No
Does moderate-to-severe coronary calcification worsen 1-year clinical outcomes in patients undergoing IVUS-guided PCI compared to no or mild calcification?
When PCI is guided by IVUS, the presence of moderate-to-severe coronary calcification does not appear to worsen 1-year clinical outcomes compared to less severe calcification.
Effect estimate: HR 1.54 (95% CI 0.85–2.79)
Absolute Event Rate: 9.4% vs 6.3%
p-value: p=0.157
Under routine IVUS-guided PCI, moderate-to-severe coronary calcification was associated with 1-year clinical outcomes comparable to those of no or mild calcification after adjustment.
Nguyen et al. (Fri,) conducted a observational in Adults (≥18 years) with angiographically confirmed coronary artery disease (chronic or acute coronary syndromes) undergoing IVUS-guided PCI (n=914). IVUS-guided PCI with systematic lesion preparation and new-generation drug-eluting stents vs. None/mild coronary artery calcification group was evaluated on 1-year major adverse cardiac events (MACE), composite of all-cause death, myocardial infarction, and target lesion revascularization (HR 1.54, 95% CI 0.85–2.79, p=0.157). Moderate-to-severe coronary calcification was not significantly associated with 1-year MACE after IVUS-guided PCI (9.4% vs. 6.3%; HR 1.54, 95% CI 0.85–2.79; p=0.157) in adults with coronary artery disease.