March 3, 2026Open Access

Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks

Key Points

DGNTG inhibits synoviocyte proliferation and migration, leading to reduced rheumatoid arthritis symptoms.
Key metric includes the mechanistic evidence based on ceRNA networks derived from MH7A cells.
Assessment using transcriptomic data of DGNTG-treated MH7A cells reveals its mechanism of action.
These findings support potential new treatments for rheumatoid arthritis but need further validation.

Abstract

This study presents evidence that DGNTG exerts anti-RA effects through the inhibition of synoviocyte proliferation, migration and invasion. Additionally, It provided a valuable resource for elucidating the mechanism of action of DGNTG by constructing a competing endogenous RNA network based on transcriptomic data obtained from DGNTG-treated MH7A cells.

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Authors

Yisi Cai

Central South University

Yanyan Song

TCM-Intigrated Cancer Center of Southern Medical University

X Zeng

TCM-Intigrated Cancer Center of Southern Medical University

Journals

SHILAP Revista de lepidopterología

Frontiers in Pharmacology

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Institutions

Southern Medical University

Nanfang Hospital

State Administration of Traditional Chinese Medicine of the People's Republic of China

Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks

Key Points

Abstract

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