Dehydroepiandrosterone activates ADGRG2 to regulate chloride homeostasis and sperm motility via Gs-cAMP pathways

Key Points

• Sperm motility was found to improve significantly with dehydroepiandrosterone treatment through Gs-cAMP signaling.
• A key finding showed that chloride homeostasis gets regulated by the activation of ADGRG2.
• The analysis utilized direct evaluation of hormone interactions and signaling pathways in reproductive models.
• Highlighting the potential role of dehydroepiandrosterone in fertility and reproductive health.