ROS-Driven Rewiring of Hippo-Inflammation-Polycomb Axis by PFOA in 2D and 3D Lung Epithelial Models

Key Points

• Rewiring of the hippo pathway and inflammation signaling occurs due to reactive oxygen species (ROS).
• The study examines both 2D and 3D lung epithelial models to capture architectural influences.
• Assessments used detailed analysis of molecular pathways to explore the roles of polycomb and inflammation.
• Findings indicate potential disruptions in gene regulation caused by PFOA exposure in lung tissues.