Dynamic visualization of butyrylcholinesterase activity in neuroinflammation and Alzheimer's disease with an activatable near-infrared fluorogenic probe

Key Points

• Altering butyrylcholinesterase activity is linked to neuroinflammation, specifically in Alzheimer's disease and related conditions.
• Significant changes were observed using an activatable near-infrared fluorogenic probe, providing real-time insights into enzyme dynamics.
• Dynamic imaging techniques facilitated the assessment of enzymatic activity, revealing specific patterns associated with neurodegeneration.
• Findings highlight the potential of using butyrylcholinesterase activity as an early indicator for neuropathological changes in Alzheimer's disease.