March 3, 2026

Mesenchymal stem cell exosomes alleviate ischemic myocardial injury by miR-125b-5p/BTG2 pathway

LLL LuoFujian Medical University LLLieyou LiFujian Medical University SWSheng-Ze WuFujian Medical University

Key Points

Exosomes significantly reduce ischemic myocardial injury through the miR-125b-5p/BTG2 pathway, indicating their therapeutic potential.
Key findings show improved heart function metrics, with noteworthy results observed in ischemic conditions.

Structured PICO

Do BMSC-derived exosomes alleviate ischemic myocardial injury via the miR-125b-5p/BTG2 pathway in murine models?

Population

Murine bone marrow mesenchymal stem cells (BMSCs) and models of ischemic myocardial injury

Intervention

Exosomes derived from murine BMSCs transfected with miR-125b-5p inhibitor

Comparator

Exosomes derived from murine BMSCs transfected with negative-control (NC) oligonucleotides

Outcome

Ischemic myocardial injury and regulatory interaction with B-cell translocation gene 2 (BTG2)surrogate

This preclinical study investigates the mechanistic role of the miR-125b-5p/BTG2 pathway in how BMSC-derived exosomes protect against ischemic myocardial injury.

Abstract

MicroRNAs mediate the protective effects of bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) against myocardial injury. This study aimed to elucidate the specific role of exosomal miR-125b-5p in ischemic myocardial injury, focusing on its regulatory interaction with B-cell translocation gene 2 (BTG2). Murine BMSCs were transfected with miR-125b-5p inhibitor or negative-control (NC) oligonucleotides and then used to generate miR-125b-5p-knockdown (miR-125b-5p

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