Overview of the Efficacy and Safety of Topical Hormonal Therapies for the Treatment of Acne Vulgaris: A Narrative Review.

Key Points

• Topical clascoterone cream 1% shows notable efficacy in treating acne vulgaris, enhancing patient outcomes.
• Evidence suggests potential benefits of topical spironolactone, though large-scale randomized controlled trials are necessary.
• Pharmacokinetic studies are needed to understand the full efficacy and safety profiles of topical hormonal therapies.
• The findings emphasize the need for more research to ensure safe and effective acne treatments for patients.