This paper presents two cases of bilateral atypical femoral fractures in postmenopausal women who underwent prolonged bisphosphonate therapy for osteoporosis. Both patients, aged 83 and 76, experienced fractures after long-term bisphosphonate treatment, highlighting concerns about suppressed bone turnover. Each case was treated with intramedullary nailing, and bisphosphonates were discontinued in favor of alternative therapies. These cases underscore the risks of atypical femoral fractures linked to extended bisphosphonate use, emphasizing the need for careful patient monitoring and further research to optimize osteoporosis treatment strategies and prevent such complications.
Jasqui-Remba et al. (Wed,) studied this question.