This case highlights the diagnostic and therapeutic challenges of dual ANCA and anti-GBM antibody positivity in the context of systemic autoimmunity. In patients with autoimmune disorders such as Sjögren's disease, a high index of suspicion is essential to detect this rare overlap, which often presents with severe kidney impairment. Although kidney prognosis is frequently poor, early identification and appropriate intervention are vital for improving clinical outcomes.
Estacio et al. (Thu,) studied this question.