A method is developed for the enantioselective determination of pharmaceutical environmental pollutants (beta-blockers, profens) by high-performance liquid chromatography using promising chiral stationary phases based on eremomycin derivatives. The specificity of the studied selectors is revealed: the phase based on eremomycin aglycone is effective for separating more polar pharmaceuticals, including β-blockers, while the phase containing chloreremomycin demonstrated high selectivity for less polar profens. A possibility of the simultaneous separation of the enantiomers of substances in multicomponent mixtures is demonstrated. A method for water sample preparation using solid-phase extraction is developed and tested. An analysis of real natural and wastewater samples confirmed the applicability of the developed approach to identifying chiral pharmaceutical contaminants.
Prosuntsova et al. (Mon,) studied this question.