What question did this study set out to answer?

This research aims to examine the relationship between sensitivity to thyroid hormones and liver fibrosis severity in individuals with normal thyroid function.

March 4, 2026Clinical and Experimental Medicine0 citationsOpen Access

Impaired central sensitivity to thyroid hormones is associated with increased liver fibrosis degree in the euthyroid population

YLYing Li JHJian Huang FWFang Wang

Key Points

This research aims to examine the relationship between sensitivity to thyroid hormones and liver fibrosis severity in individuals with normal thyroid function.
Analyzed central thyroid hormone sensitivity using TFQI, TSHI, and TT4RI.
Measured liver stiffness via liver shear wave quantification ultrasonography.
Conducted statistical analysis to evaluate correlations between sensitivity indices and liver stiffness values.
Higher TFQI, TSHI, and TT4RI found in individuals with liver stiffness ≥ 7.3 kPa.
Positive correlation between liver stiffness and TT4RI (β = 0.413, P < 0.001).
Stronger correlations observed in females and individuals under 65 years with lower BMI.

Abstract

To analyse the relationship between central sensitivity to thyroid hormones (THs) and liver fibrosis in a euthyroid population. Central TH sensitivity indices, including the thyroid feedback quantile-based index (TFQI), thyroid stimulating hormone index (TSHI), and thyrotropin thyroxine resistance index (TT4RI), were calculated according to TH levels. Liver stiffness measurement (LSM) values were determined by liver shear wave quantification ultrasonography, and statistical analysis of the above data was conducted. Compared with those in the LSM 2 group. Central TH sensitivity decreases as the degree of fibrosis increases in the euthyroid population, particularly among females, individuals aged 2 within certain ranges.

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Cite This Study

Li et al. (Mon,) studied this question.

synapsesocial.com/papers/69a7cd3dd48f933b5eed9593 https://doi.org/https://doi.org/10.1007/s10238-026-02094-7

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