Control of site-specific deprotonation through mechanochemical interconversion of two ionic cocrystal forms of resveratrol

Key Points

• This research aims to investigate how mechanical processes can control the deprotonation of resveratrol when combined with ionic cocrystal forms.
• Utilized mechanochemical techniques to interconvert cocrystal forms of resveratrol.
• Analyzed changes in deprotonation at specific sites within the cocrystals.
• Examined the effects on drug properties and efficacy.
• Successfully demonstrated site-specific deprotonation control through mechanochemical methods.
• Showed that different ionic cocrystal forms can alter the drug's properties.
• Identified potential for improved efficacy in drug applications.