What question did this study set out to answer?

The aim is to identify the causes and potential treatments for chronic, noninfectious diarrhea.

March 4, 2026JAMA7 citations

Chronic, Noninfectious Diarrhea

PSPrashant Singh ALAllen Lee NSNeil M. Sheth

Key Points

The aim is to identify the causes and potential treatments for chronic, noninfectious diarrhea.
Review of common causes such as IBS-D and functional diarrhea.
Diagnostic testing considerations for celiac disease, inflammatory bowel disease, and microscopic colitis.
Assessment of lifestyle and dietary modifications as well as medication options.
IBS-D and functional diarrhea are identified as common contributors to chronic diarrhea.
Patients may require diagnostic testing to rule out conditions like celiac disease.
Effective empirical therapies include dietary changes and medications such as opiate agonists, anticholinergics, and 5-HT3 antagonists.

Abstract

The most common causes of chronic, noninfectious diarrhea include IBS-D and functional diarrhea. Diagnostic testing should include consideration of celiac disease, inflammatory bowel disease, and microscopic colitis. Empiric therapies for chronic diarrhea include lifestyle and dietary modifications and medications, including opiate agonists, anticholinergics, and 5-HT3 antagonists.

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