What question did this study set out to answer?

To evaluate the adequacy of current cloxacillin prophylaxis dosing for patients undergoing hip and knee arthroplasty.

March 4, 2026Journal of Antimicrobial Chemotherapy0 citationsOpen Access

Is current guidance for cloxacillin prophylaxis dosages in hip and knee arthroplasty adequate? Evidence from a prospective Swedish cohort

KWKatja Wallander GBGustaf Beijer EEErik Eliasson

Key Points

To evaluate the adequacy of current cloxacillin prophylaxis dosing for patients undergoing hip and knee arthroplasty.
Prospective cohort study conducted in Sweden
Assessment of cloxacillin dosing in relation to body weight
Evaluation of renal function in patients
Identified risk for subtherapeutic cloxacillin levels in high body weight patients
Current dosing guidelines may not be suitable for preserving therapeutic levels

Abstract

Current cloxacillin dosing in hip and knee arthroplasty surgery results in a risk for subtherapeutic levels in patients with high body weight and preserved renal function. Therefore, dosing guidelines for cloxacillin prophylaxis in arthroplasty should be reviewed.

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