What question did this study set out to answer?

This research aims to explore the relationship between oxidized albumin levels and mortality rates in critically ill Covid-19 patients.

March 4, 2026Intensive Care Medicine Experimental0 citationsOpen Access

Oxidized albumin and its association with mortality in critically ill Covid-19 patients: a retrospective cohort study

TATeun E.M. Aben LHLars Hedlund JGJonathan Grip

Key Points

This research aims to explore the relationship between oxidized albumin levels and mortality rates in critically ill Covid-19 patients.
Retrospective cohort study design
Comparison of oxidized albumin levels in Covid-19 patients versus healthy controls
Assessment of hospital mortality and correlation with HNA-1, creatinine levels, and SOFA scores
Elevated oxidized albumin levels were not linked to increased hospital mortality in Covid-19 patients
Higher HNA-1 levels correlated with increased creatinine and SOFA scores
Findings enhance understanding of oxidized albumin in critically ill Covid-19 patients

Abstract

Fractions of HNA-1 were higher in Covid-19 patients compared to healthy controls. In critically ill Covid-19 patients elevated levels of oxidized albumin were not associated with higher hospital mortality. Higher HNA-1 levels were associated with higher creatinine levels and higher SOFA scores. These findings contribute to increased knowledge about oxidized albumin in critically ill Covid-19 patients and can inspire future research.

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