What question did this study set out to answer?

The aim is to develop a method for creating carbon-fluorine bonds using a free radical approach.

March 4, 2026

Cu(I)-catalyzed, N-Fluorobenzamides Enabling 1,2-Carbofluorination of Unactivated Alkenes via Free Radical Relay

HJHong JiNankai University HQHaifeng QiaoNankai University BWBoyi WangNankai University

Key Points

The aim is to develop a method for creating carbon-fluorine bonds using a free radical approach.
Utilized Cu(I) as a catalyst for the reaction
Employed N-fluorobenzamide as a reactant
Focused on the bifunctionalization of unactivated alkenes
Successfully formed carbon-fluorine bonds in unactivated alkenes
Demonstrated the effectiveness of free radical relay in acarbon-fluorine formation
Revealed the potential for broad application in organic synthesis

Abstract

The construction of carbon-fluorine bond has always remained challenging. This work described a two-component 1,2carbofluorination bifunctionalization of unactivated alkenes through a free radical relay process. The N-fluorobenzamide was firstly used...

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