The MAGGIC clinical risk score demonstrated moderate discrimination for all-cause death in HFpEF with a C-statistic of 0.74 (95% CI 0.68–0.80), outperforming or matching other scores.
Do clinician-usable prognostic scoring systems accurately stratify risk and predict outcomes in patients with heart failure with preserved ejection fraction?
A layered, phenotype-aware prognostic strategy integrating clinical risk, biomarkers, and dynamic congestion assessment outperforms single static baseline scores in HFpEF.
Effect estimate: MAGGIC C-statistic 0.74 (95% CI 0.68–0.80) (95% CI 0.68–0.80)
HFpEF prognostication is best supported by a layered, phenotype-aware strategy. This approach integrates global clinical risk, selected biomarkers, discharge congestion assessment, and serial reassessment, rather than relying on a single score.
Draghici et al. (Mon,) conducted a review in Adults with heart failure with preserved ejection fraction (HFpEF), varying phenotypes and settings including acute hospitalization, post-discharge, and ambulatory care. The MAGGIC clinical risk score demonstrated moderate discrimination for all-cause death in HFpEF with a C-statistic of 0.74 (95% CI 0.68–0.80), outperforming or matching other scores.