Dynamics of gut bacteriophage in diversity outbred mice studied over lifespan and during extreme caloric restriction

Key Points

• The research aims to explore the dynamics of gut bacteriophage populations over the lifespan of diversity outbred mice and under extreme caloric restriction.
• Longitudinal study design assessing mice over their lifespan
• Monitoring gut bacteriophage populations
• Application of caloric restriction to observe effects
• Highlight the dominance of 'piggyback-the-winner' strategies in phage dynamics
• Show variations in bacteriophage diversity linked to lifespan stages
• Uncover the impact of caloric restriction on gut microbial balance

Abstract