What question did this study set out to answer?

To identify prognostic factors for relapse in individuals with their first episode of idiopathic hypertrophic pachymeningitis through measurements of dura mater thickness.

March 5, 2026Open Access

Insufficient Dural Thickness Recovery in Acute Treatment Predicts Subsequent Relapses in Idiopathic Hypertrophic Pachymeningitis

STSunao TakahashiOsaka Neurological Institute MSMotohiro SuzukiOsaka Neurological Institute JOJun Oyama

Key Points

To identify prognostic factors for relapse in individuals with their first episode of idiopathic hypertrophic pachymeningitis through measurements of dura mater thickness.
Measured the thickness of hypertrophic lesions of the dura mater in patients with idiopathic hypertrophic pachymeningitis.
Assessed responses to corticosteroid treatment over time.
Analyzed potential biomarkers correlated with relapse risk.
Insufficient recovery of dura mater thickness was linked to a higher likelihood of subsequent relapses.
Observed mixed responses to corticosteroid treatment among patients.
No definitive biomarkers for relapse were identified, indicating a need for further research.

Abstract

Objective Idiopathic hypertrophic pachymeningitis (IHP) is an inflammatory disease of the dura mater of an unknown underlying cause. Although corticosteroids are commonly used as a first-line treatment, mixed responses have been observed. Furthermore, biomarkers for predicting relapse independent of various symptoms and lesion morphology have not yet been identified. We aimed to identify the prognostic factors of relapse in the first episode of IHP by objectively measuring the thickness of hypertrophic lesions of the dura mater.

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