Decidual immune activation by extravillous trophoblasts drives maternal-fetal tolerance and immunity

Key Points

• The aim is to understand how extravillous trophoblasts influence maternal immune responses to maintain pregnancy.
• Review of existing research on maternal-fetal interactions during pregnancy
• Discussion of key EVT ligands and their role in immune cell activation
• Analysis of decidual natural killer and T cells in relation to placentation and immunity
• Extravillous trophoblasts activate decidual natural killer and T cells
• Activation of these immune cells promotes immune tolerance and supports successful placentation
• Further research is needed to clarify unresolved questions about these mechanisms.