What question did this study set out to answer?

To explore how Muribaculum intestinale affects depressive-like behaviors and related immune mechanisms.

March 5, 2026Microbiome1 citationsOpen Access

Muribaculum intestinale alleviates depressive-like behaviors by inhibiting Th17 cell differentiation and M1 microglia polarization

Key Points

To explore how Muribaculum intestinale affects depressive-like behaviors and related immune mechanisms.
Investigated the role of Muribaculum and SCFAs in depression models.
Examined Th17 cell differentiation and M1 microglia polarization.
Evaluated antidepressant-like effects of loganin in preclinical settings.
Loganin enriched Muribaculum and increased SCFA levels.
Inhibition of Th17 cell differentiation was observed with Muribaculum.
Reduced M1 microglia polarization linked to improved depressive-like behaviors.

Abstract

Loganin exerts antidepressant-like effects by enriching Muribaculum and SCFAs, thereby inhibiting Th17 cell differentiation and M1 microglia polarization. M. intestinale may represent a promising microbial-based therapeutic strategy for depression.

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Cite This Study

He et al. (Tue,) studied this question.

synapsesocial.com/papers/69a91cf1d6127c7a504bfd18 https://doi.org/https://doi.org/10.1186/s40168-026-02354-4

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