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A single session of anodal transcranial direct current stimulation does not produce an effect on exercise-induced hypoalgesia in patients with knee osteoarthritis. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 5, 2026Neuromodulation Technology at the Neural Interface0 citationsOpen Access

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No Effect of a Single Session of Anodal Transcranial Direct Current Stimulation on Exercise-Induced Hypoalgesia in Knee Osteoarthritis: A Randomized Cross-Over Trial

DTDavid Toomey GLGwyn N. Lewis URUsman Rashid

Key Points

To assess the impact of anodal transcranial direct current stimulation on exercise-induced pain relief in knee osteoarthritis.
Conducted as a randomized cross-over trial
Participants underwent two sessions with and without stimulation
Measured pain responses after exercise
No significant difference in pain reduction was found between stimulation and non-stimulation sessions
Exercise did not enhance pain relief during the stimulation period

Abstract

The Australian New Zealand Clinical Trials Registry number for the study is ACTRN12621000787886, registered July 1, 2021, prospectively.

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No Effect of a Single Session of Anodal Transcranial Direct Current Stimulation on Exercise-Induced Hypoalgesia in Knee Osteoarthritis: A Randomized Cross-Over Trial

Key Points

Abstract

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