Nine novel functionalized 2,5-diaryloxazolo4,5- d pyrimidin-7-ylamines were designed, synthesized and characterized using 1 H, 13 C NMR, IR spectroscopy, elemental analysis, and liquid chromatography–mass spectrometry . Their anticancer activity was assessed against human cancer cell as well as non-cancer cell lines. Three compounds, 1 , 3 , and 9 , were the most cytotoxic to HeLa cells (IC 50 = 6.13 ± 1.95, 13.99 ± 1.80 and 49.92 ± 3.98 μM, respectively). However, only compounds 1 , 7 , and 9 were selective against the tested lines. Compound 9 can be classified as the most attractive and promising candidate for further development against cervical adenocarcinoma.
Hodyna et al. (Tue,) studied this question.