What question did this study set out to answer?

To develop a multifunctional hydrogel aimed at improving healing in diabetic chronic infectious wounds.

March 5, 2026Journal of Materials Chemistry B0 citations

Microenvironment-Responsive Hydrogel with Photothermal, Antioxidant, and Neuroregenerative Functions for Diabetic Chronic Infectious Wound Healing

Key Points

To develop a multifunctional hydrogel aimed at improving healing in diabetic chronic infectious wounds.
Constructed a hydrogel using dynamic boronate crosslinking.
Analyzed hydrogel's responsiveness to microenvironmental factors.
Evaluated photothermal, antioxidant, and neuroregenerative properties.
Hydrogel effectively reduced oxidative stress in wounds.
Promoted vascularization and tissue regeneration.
Showed potential to mitigate persistent infections in diabetic wounds.

Abstract

Diabetic chronic infectious wounds (DCIW) remain a clinical challenge due to impaired vascularization, persistent infection, and excessive oxidative stress. Here, we report a multifunctional microenvironment-responsive hydrogel constructed via dynamic boronate...

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