Total Synthesis of (+)-Raistrickindole A

Key Points

• The aim is to complete the total synthesis of the alkaloid (+)-raistrickindole A.
• Used a stereochemical relay strategy for synthesis.
• Employed an intermolecular nitroso Diels-Alder cycloaddition.
• Achieved regio- and diastereoselective core formation of a 3,4-dihydro-1,2-oxazine.
• Implemented a stereoselective Mukaiyama hydration in the later stages.
• Successfully completed the total synthesis of (+)-raistrickindole A.
• Demonstrated effective regio- and diastereoselectivity in cycloaddition.
• Showed that the hydration step could be performed stereoselectively.