MLPH/RAB3A accelerates the differentiation of pancreatic stem cells to islet β-cells to control blood glucose in diabetic rats.

Key Points

• The aim is to investigate the role of MLPH and RAB3A in the differentiation of pancreatic stem cells into insulin-producing beta-cells.
• Examined the effects of MLPH overexpression on pancreatic stem cells (PSCs).
• Transplanted MLPH-overexpressing PSC-β cells into diabetic rats.
• Measured the ability to manage glycemic loads using physiological assessments.
• MLPH overexpression significantly enhanced the differentiation of PSCs into insulin beta-cells.
• Transplantation led to restored glycemic control in T1D rats after MLPH-overexpressing PSC-β cell treatment.
• RAB3A expression was promoted, contributing to the improved function of beta-cells.