Perihematomal Edema and Functional Outcome After Intracerebral Hemorrhage: A Meta-Analysis of Individual Participant Data

Key Points

• The study aims to evaluate the association of perihematomal edema growth with functional outcomes after intracerebral hemorrhage.
• Conducted a meta-analysis of individual participant data
• Analyzed data focusing on the growth of perihematomal edema
• Examined outcomes after 24 and 72 hours of intracerebral hemorrhage onset
• PHE growth within 24 hours is strongly linked to increased risk of death or dependence
• PHE growth at 72 hours also correlates with poorer outcomes
• Independently predicts functional status after intracerebral hemorrhage