Plasma proteomic profiles of lung volume-based phenotypes in Tobacco-Exposed Individuals Without Spirometric COPD

Key Points

• This research aims to identify distinct lung volume-based phenotypes and their associated plasma proteomic profiles in individuals exposed to tobacco.
• Utilized lung volume-based stratification to categorize tobacco-exposed individuals.
• Analyzed plasma proteomic profiles to identify different biological signatures.
• Compared the proteomic data to assess differences in COPD risk across subgroups.
• Identified biologically distinct subgroups among tobacco-exposed individuals based on lung volume.
• Uncovered differing plasma proteomic signatures associated with early COPD risk.
• Highlighted potential circulating biomarkers predictive of pre-COPD conditions.