The combination of IC and chemoradiotherapy demonstrated promising tumor control and laryngeal preservation in patients with LSCC. SIK1 has emerged as a potential diagnostic and prognostic biomarker, with its expression levels correlating with key clinicopathological factors and survival outcomes. These findings highlight the need for further investigation into the clinical and mechanistic roles of SIK1 in LSCC.
Gharib et al. (Sun,) studied this question.