( Br J Anaesth . 2025;135:1231-1239. doi: 10.1016/j.bja.2025.07.077) This study examined how labor epidural analgesia (LEA) affects the body’s sympathetic nervous system, particularly its role in thermoregulation. Epidural-related maternal hyperthermia (ERMH), a rise in maternal core temperature above 38 °C during labor, is a common complication linked to adverse maternal and neonatal outcomes. The study sought to determine whether LEA suppresses cholinergic and noradrenergic sympathetic function, thereby reducing the body’s ability to dissipate heat.
Iacona et al. (Sun,) studied this question.