VEGF-Positive Mass-Forming Intrahepatic Cholangiocarcinoma: New Subtype Based on Radiological and Molecular Pathological Analysis.

Key Points

• The aim is to identify a new subtype of intrahepatic cholangiocarcinoma (H-ICC) characterized by specific radiological and molecular features.
• Dynamic CT imaging to assess tumor characteristics
• Analysis of vascular density (AVD)
• VEGF expression evaluation through immunostaining
• H-ICC exhibits hyperenhancement in ≥ 50% of tumor area on CT scans
• H-ICC shows high levels of AVD
• Distinct clinicopathological subset identified by LAP enhancement and VEGF expression