What question did this study set out to answer?

To investigate the role of CX3CR1/P2X4R signaling in spinal microglial M1 polarization and its contribution to chronic pelvic pain in endometriosis.

March 8, 2026Open Access

CX3CR1/P2X4R signaling-mediated spinal microglial M1 polarization contributes to chronic pelvic pain in endometriosis

Key Points

To investigate the role of CX3CR1/P2X4R signaling in spinal microglial M1 polarization and its contribution to chronic pelvic pain in endometriosis.
Examined the CX3CR1/P2X4R pathway in spinal microglia
Analyzed lesional inflammation and vascular pathology
Investigated interactions contributing to chronic pelvic pain
Identified a synergistic mechanism involving inflammation and microglial polarization
Noted significant microglial M1 activation associated with chronic pelvic pain
Highlighted potential of targeting CX3CR1/P2X4R pathway for pain management

Abstract

This study revealed a synergistic mechanism whereby lesional inflammation, vascular pathology, and spinal microglial M1 polarization collectively contribute to CPP in endometriosis. The CX3CR1/P2X4R-NFκB pathway represents a promising therapeutic target for endometriosis-associated chronic pain.

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Discussion

Authors

Qianyu Wu

Fan Yang

Ruyu Yang

Journals

International Immunopharmacology

Actions

Institutions

Sun Yat-sen University

University of Macau

Southern Medical University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

CX3CR1/P2X4R signaling-mediated spinal microglial M1 polarization contributes to chronic pelvic pain in endometriosis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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